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Many patients also received concomitant standard therapy, making interpretation of efficacy difficult. Passive immunizations with IVIG have been reported to be successful in several small series, including both children and adults.
A recent review concluded that the grade of evidence is weak, given the lack of RCTs (125). One exception may be patients with hypogammaglobulinemia, which is common in patients following solid organ transplants, and may predispose to CDI. In one study, there was a fivefold increased risk of CDI in heart transplant recipients.